Abstract:

All of us have suffered from acidity at some point or other. Severe pain in the stomach, burning, bloating, hiccupping, flatulence, and acid reflux is the common symptoms. While our immediate and natural response is to reach for that antacid when suffering from acidity, it will not give you long-term relief. Instead, we suggest, opt for these Herbal treasures to cure and control acidity and boost your overall stomach health. We give you the most effective remedies for acidity, heartburn, and indigestion. The present article is an overall review of herbal formulations used in all different fields like Ayurvedha, Sidha, and the Unani system of medicine to educate people about the benefits of herbal formulations and their uses. Gastric acidity is a common clinical problem, affecting millions of people worldwide. patients are recognized by both classic and atypical symptoms. Here, we discuss a detailed review of herbal medicines marketed & available in India for the management of gastric acidity. You get detailed information about tablets, capsules & syrups for acidity and their combinations. 

Abstract:

Gastric ulcer is a chronic disease featured with unexpected complications, including bleeding, stenosis and perforation, as well as a high incidence of recurrence. Clinical treatments for gastric ulcer have allowed the rapid development of potent anti-ulcer drugs during the last several decades. Gastric ulcer healing is successful with conventional treatments including H2-receptor antagonists, and proton pump inhibitors (PPIs) have been essential for ulcer healing and prevention of complications. Additionally, Helicobacter pylori eradication therapy is effective in reducing ulcer recurrence and leads to physiological changes in the gastric mucosa which affect the ulcer healing process. However, in spite of these advancements, some patients have suffered from recurrence or intractability in spite of continuous anti-ulcer therapy. A new concept of the quality of ulcer healing (QOUH) was initiated that considers the reconstruction of the mucosal structure and its function for preventing ulcer recurrence. Although several gastroprotection provided these achievements of the QOUH, which PPI or other acid suppressants did not accomplish, we found that gastroprotection that originated from natural products, such as a newer formulation from either Artemisia or S-allyl cysteine from garlic, were very effective in the QOUH, as well as improving clinical symptoms with fewer side effects. In this review, we will introduce the importance of the QOUH in ulcer healing and the achievements from natural products.

Abstract:

Acidity is a medical condition caused by an excess of acid production. This acid is produced by the stomach glands. Acidity causes symptoms such as stomach ulcers, gastric inflammation, heartburn, and dyspepsia. Acidity is a global issue caused by an imbalance between the acid-secreting mechanisms of the stomach and the proximal intestine. It causes a lot of problems in the lives of many people. An antacid reduces acidity and provides relief. This review article discusses different polyherbal formulations (PHF) used to treat gastric acidity. Due to its role in medicine and therapy, PHF has been used all over the world. The current study discusses a variety of commercial and non-commercial polyherbal formulations used worldwide to treat gastric acidity, as well as their therapeutic potential, clinical and preclinical outcomes, and safety and efficacy. This review will make it easier to learn everything about the previous scientific research as well as the crucial details about the antacid properties of polyherbal preparations, which will encourage young researchers to conduct additional studies in the future to protect people from gastric acidity. Natural herbs and their extracts are used in herbal treatment as an alternative to conventional medication to treat various conditions. It has been demonstrated that several medications contain medicinal components useful for treating ulcers or stomach acidity. The subject of the current work is the claim that a polyherbal formulation can be utilised as an alternative to currently available antacid formulations on the market. As a result, those plants that can reduce stomach acid are chosen, and a formulation is created.

Abstract:

An ulcer in the stomach is a common digestive system ailment. Gastric ulcers are more likely to develop if one drinks alcohol regularly. Despite the extensive availability of treatment options, there are just a few preventative regimes. In animal trials, herbal remedies have been found to prevent the formation of ethanol-induced stomach ulcers. Histamine receptor 2 antagonists have a similar or higher ability to inhibit the formation of ethanol-induced stomach ulcers to herbal treatments. There are less adverse effects associated with herbal remedies. PubMed, Google Scholar, and Web of Science databases were searched using keywords such as "gastric ulcer," "herbal medicines," and "ethanol-induced gastric injury." The search was performed up to May 15, 2021. Only articles published in English were used in this review. For those who are more susceptible to develop stomach ulcers, certain herbal combinations may be an effective option to prevent the development of gastric ulcers, based on their methods of action and the pathogenesis of gastric ulcers. Dates, pomegranate seeds, and bitter melon are all examples of herbal compounds that are safe and can be ingested. Those who regularly use alcohol may want to consider using these substances as an alternative method of preventing stomach ulcers. Anti- Helicobactor pylori herbal components such as Mitrella kentia, citrus lemon, and Cratoxylum arborescens (Vahl) Blume can be used by Helicobacter pylori-positive individuals to avoid the creation of ethanol-induced stomach ulcers.

Abstract:

Oxidative stress is a key cause of gastrointestinal disorders, primarily stomach ulcers. Multiple intrinsic and extrinsic mechanisms caused the body to produce reactive oxygen species (ROS). The body's antioxidant defense system protects against these reactive species. When the degree of ROS production exceeds the normal range, the body's natural defense system fails to neutralize these dangerous free radicals, necessitating need foran exogenous source of natural antioxidants. Natural herbal remedies have been widely employed as antioxidants to relieve oxidative stress in gastric ulcers. Polyphenols, tannins, essential oils, flavonoids, notably quercetin, carotenoids, vitamin C, vitamin A, and minerals are among the molecules of immense interest in bioassays due to their significant antioxidant effects. In the present review, several natural anti-ulcer medicinal plants along with their antioxidative mechanism have been reported. Electronic databases including PubMed, Google Scholar and Scopus were explored to identify the antioxidant and gastroprotective potential of all the plants.

Abstract:

: Herbal treatment is the form of medicine which include herbs and this herbs are used in situation such as treatment of gastric acidity or ulcers [1]. A Shadanga Paniya is a popular Ayurvedic formulation which contain natural herbs and the formulation is used in hyper acidity, ulcerative dyspepsia and other acid peptic disorders [2] .By formulating ayurvedic powder into tablet the dosage uniformity and patient compliance can be increased and adultration can be decreased [3] . The present work deals with develop and evaluate Shadanga Paniya tablets using starch and acacia as a binder. By selected herbs with the tendency to neutralize acid in the stomach are selected and a tablet is formed [4] . The acid neutralizing capacities of the herbs were analyzed by Back titration method [4] . After the back titration the tablets were prepared and this prepared tablets were evaluated for different parameters such as weight variation, thickness uniformity, hardness, friability, disintegration time and acid neutralizing capacity (ANC) [4] . Herbal drug shows fewer side effects as compare to OTC drugs. So nowadays peoples are moving towards herbal products. So, present study is based on back titration for the herbal drugs used for acidity and formulate them into tablet dosage form and evaluate them.

Abstract:

BACKGROUND An ulcer is a condition characterized by inflammation, irritation, or erosion in the mucosal lining of the stomach or duodenum. Hence, peptic ulcer is the ulcer of both the stomach and the duodenum. 10% of the world's population is affected by chronic peptic ulcers. The formation of peptic ulcers depends on gastric juice pH and the decrease in mucosal defenses. Nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two significant factors disrupting mucosal resistance to injury. Indian herbal plants are exceptional for their ethnic, ethnobotanical, and ethno-pharmaceutical use. In this review, attempts have been made to gain information regarding some plants that may be used to treat or prevent peptic ulcers. The ultimate goal of peptic ulcer disease treatment is to reduce pain, cure ulcers, and prevent recurrence. OBJECTIVE The aim of the study was to gain knowledge about several common medicinal plants employed in Ayurveda or contemporary science for the treatment or prevention of peptic ulcers and some natural and simple approaches to cure ulcers using readily available herbs. METHOD The literature search was carried out using search engines, like Google Scholar, Scopus, PubMed, Medline, Springer, etc. Results: The extensive literature search showed natural herbs to have potential anti-ulcer activity, including cabbage, bananas, liquorice, fenugreek, garlic, Terminalia chebula, Acacia arabica, Aegle marmelos, Aloe vera, Allium sativum, Plantago ispagula, Mimosa pudica, Annona squamosa, Azadirachta indica, and Galega purpurea. CONCLUSION This study concluded several medicinal plants to effectively prevent or cure peptic ulcers caused by a variety of factors, including H. pylori, aspirin, indomethacin, alcohol, and others.

Abstract:

Gastric ulcers are a common problem in upper gastrointestinal tract (GI) disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most aggressive factors leading to inducing gastric ulcers. Natural products with lower toxicity and safety are currently sought as a potential source to minimize the effect of the gastric ulcers. Perilla frutescens or Nga-mon (in Thai) leaves are rich in rosmarinic acid (RA), which has antioxidant, anti-inflammatory, and anticancer effects. This study investigates the protective effect of ethanolic extract (EE) and aqueous fraction (AF) from Perilla frutescens leaves, which are rich in RA, on indomethacin- (IND-) induced gastric ulcer in a rat model. The EE at the doses of 50 and 500 mg/kg body weight, AF at the doses of 50, 250, and 500 mg/kg body weight, or famotidine (a standard drug) were administered for 14 days prior to ulcer induction. The ulceration was performed by intragastric administration of IND. Gross gastric ulcers and biological and histological parameters were examined. The pretreatment with AF had more significant effects than EE, including reduced ulcer index, decreased gastric secretion volume and decreased acidity, but it had an elevated gastric pH relative to the IND-induced gastric ulcer. In a histopathological study, the EE and AF decreased mucosal ulcer, inflammatory infiltration, and degenerative lining cells. The IND-induced expression of inflammatory mediators was significantly attenuated with EE and AF. The experiment also remarkably showed the preservation of mucus and apoptosis protection of EE and AF on a gastric mucosal ulcer. The findings demonstrated that the EE and AF of perilla leaves were capable of protecting the stomach against gastric ulcers induced by IND through anti-inflammatory and antiapoptotic mechanisms that should be further investigated. It is suggested that Perilla frutescens leaf could be a potential alternative source of RA as a therapeutic agent and food supplement for NSAID-induced gastric injuries.

Abstract:

Stomach ache is one of the most chronic and debilitating abdominal pains. Medicinal plants are one of the most accessible sources for treating diseases like gastrointestinal disorders. In this review, we investigate and report the most important medicinal plants recommended by Persian medicine for treating stomach aches and comparing them with their proven effects in modern medicine. Gastric pain was probed in Persian medicine reliable textbooks such as Cannon of Medicine (Ibn Sina), Tibbe-Akbari (Muhammad Akbar Arzaani ), The Complete Art of Medicine (Kitab Kamil as-Sinaa at-tibbiyya) (Haly Abbas), Explanation of insults and signs (Kermani) Tohfeh Al-Mo’menin (Seyed Mohammad Momen Tonekaboni), and some notes were taken. The results showed that Panicum miliaceum, Punica granatum, Solanum nigrum, Calicotome spinosa, Tamarindus indica, Cuminum cyminum, Prunus domestica, Matricaria recutita, Viola odorata, Plantago psyllium, Berberis vulgaris, Pyrus communis, Linum usitatissimum, Vitis vinifera were the most important plant sources used in treating the stomach ache according to Persian medicine. The findings of this study showed that the useful effects of many recommended plants in Persian medicine are confirmed by recent scientific researches and are reliable. *Correspondence to:

Abstract:

: Ulcer is a broad term that include injury to the stomach and duodenal The formation of peptic ulcer depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. There are different type of ulcer . ulcer is dangerous disease that cause the breakdown of the inner lining of the stomach. ulcer is found in the mouth also. Ulcer is caused due to the consumption of alcohol, beverage, coffee etc. the fast food, spicy food, late night meal etc. are the reason of the ulcer formation. There is different herbal plant used in the treatment of the ulcer. the herbal plant having no side effect .it gives fast relief from the ulcer. there are the different herbal plant used traditionally in the treatment of ulcer i.e. Ocimum sanctum, carica papaya L, punica granatum, Agle marmelos ,hibiscus rosa sinenesis ,magnifera indica ,zingiber officinalis ,cupehea aequipetala ,mimosa pudica ,moringa oleifera ,emblica officinalis etc. this all plant are used in the treatment of the ulcer .the plant having no more side effect .the herbal formulation is used in the treatment. the treatment and having no adveres effect .now a day the modern technique are established to treat the ulcer. Now a day the ulcer can completely treated with the help of herbal plant. the other drugs having the side effect and that is harmfull to our body that’s why the herbal plant is used in the treatment of the ulcer.

Abstract:

Gastric ulcer is a chronic condition that occurs when the mucosa of the stomach is broken. There is a physiological equilibrium between aggressive factors and mucosal defense. The purpose of this research was to compare the prevention level and efficiency of herbal medicinal plants (Punica granatum) to the omeprazole drug. Many groups were prepared from Albino male rats, the first control group (inoculate with H. pylori and fed with standard pellet), the Second group, rats inoculated by H. pylori and prevented with Punica granatum aqueous extracts (PGAE) in two dosages (250mg/kg, 500mg/kg), and last group inoculated by H. pylori and prevented with standard drug omeprazole at the dose (20mg/kg). The results showed that the Ulcer Inhibition % of Punica granatum with a high dose of 500mg/kg and a low dose of 250mg/kg was 84.60±5.48 and 42.87±7.14, respectively. While in the omeprazole treatment group, Ulcer Inhibition % was 24.50±6.35 and this Ulcer Inhibition %  in the Punica granatum treatment groups was significant compared to the omeprazole treatment group and the control group (P=0.0001). PGAE displayed a significant lessening in stomach index and infectious cell proliferation with much cell damage. Although the result of the current study improves, a high dosage of aqueous extracts of plants has more effectiveness than a low dosage of aqueous extracts plants.

Abstract:

Gastric acidity is likely a key factor shaping the diversity and composition of microbial communities found in the vertebrate gut. We conducted a systematic review to test the hypothesis that a key role of the vertebrate stomach is to maintain the gut microbial community by filtering out novel microbial taxa before they pass into the intestines. We propose that species feeding either on carrion or on organisms that are close phylogenetic relatives should require the most restrictive filter (measured as high stomach acidity) as protection from foreign microbes. Conversely, species feeding on a lower trophic level or on food that is distantly related to them (e.g. herbivores) should require the least restrictive filter, as the risk of pathogen exposure is lower. Comparisons of stomach acidity across trophic groups in mammal and bird taxa show that scavengers and carnivores have significantly higher stomach acidities compared to herbivores or carnivores feeding on phylogenetically distant prey such as insects or fish. In addition, we find when stomach acidity varies within species either naturally (with age) or in treatments such as bariatric surgery, the effects on gut bacterial pathogens and communities are in line with our hypothesis that the stomach acts as an ecological filter. Together these results highlight the importance of including measurements of gastric pH when investigating gut microbial dynamics within and across species.

Abstract:

Introduction: The goal of the current study was to create and assess herbal floating tablet that would treat stomach ulcers. Many of the medications that are currently on the market have either been directly or indirectly produced from plants, which have long been considered an experimental source of medication. Different diseases are treated with plant extracts. There are so many chemically active components in plants that can be used to cure so many different diseases. Herbal floating tablet increase bioavailability, extend the period that pharmaceuticals stay in the stomach, and make it easier to administer medications locally to the stomach. For the treatment of gastric ulcers, floating tablets with alcoholic extract of amla as the primary active ingredient were created in this study. Method: The herbal floating tablet was made using the direct compression method and contains alcoholic extracts of amla, aqueous extracts of ginger and fenugreek, psyllium husk, HPMC K100M, sodium bicarbonate, talc, and magnesium stearate. Additional evaluation tests for the herbal floating tablet include those for hardness, thickness, diameter, weight uniformity, and buoyancy duration. The use of buoyancy time improved the formulation. The tablet were made using the direct compression process and contained alcoholic extract of amla, aqueous extract of ginger and fenugreek, psyllium husk, HPMC K100M, sodium bicarbonate, talc, and magnesium stearate. For gastro retentive drug delivery systems, a combination of psyllium husk, sodium bicarbonate, and HPMC K100M can prove promising.